Side Effects of Excess Vitamin D

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Vitamin D is a key nutrient because it helps your body absorb dietary calcium

so you can have strong, healthy bones. That’s why it’s important to get enough of it. But it’s also possible to get too much vitamin D—referred to as vitamin D toxicity. While this is rare, it can still be useful to know the common signs of too much vitamin D—particularly if you take vitamin D supplements regularly. Here are some of the side effects curated by Aussie online casino.

1. Elevated blood levels

In order for vitamin D to reach toxic or dangerous levels in the body, it needs to exceed 100 nanograms (ng) per mL. Hypervitaminosis D is defined as blood vitamin D levels over 100 ng/mL, while vitamin D intoxication is defined as serum levels over 150 ng/mL. Recommendations on optimal vitamin D levels vary, but research suggests that levels between 30–60 ng/mL are likely optimal and may help protect against illness and disease. Even when taking high dose vitamin D supplements, it’s unlikely that a healthy person’s blood vitamin D levels would come close to reaching excessive or toxic levels. Most cases of vitamin D toxicity are caused by inappropriate supplement dosing and prescription errors.

2. Elevated blood calcium levels

Vitamin D helps your body absorb calcium from the food you eat. In fact, this is one of its most important roles. However, if your vitamin D intake is excessive, your blood calcium may reach levels that can cause unpleasant and potentially dangerous symptoms. The symptoms of vitamin D toxicity are primarily related to hypercalcemia, which means excessively high blood calcium levels.

Symptoms of hypercalcemia include:

digestive distress, such as vomiting, nausea, constipation, and stomach pain
fatigue, dizziness, hallucinations, and confusion
loss of appetite
excessive urination
kidney stones, kidney injury, and even kidney failure
high blood pressure and heart abnormalities

3. Gastrointestinal symptoms 

The main side effects of excessive vitamin D levels are related to excessive calcium in the blood. Some of the main symptoms of hypercalcemia include:

poor appetite
However, not all people with hypercalcemia experience the exact same symptoms. One woman experienced nausea and weight loss after taking a supplement that was later found to contain 78 times more vitamin D than stated on the label. Importantly, these symptoms occurred in response to extremely high doses of vitamin D3, which led to calcium levels greater than 12 mg/dL. In one case study, a boy developed stomach pain and constipation after taking improperly labeled vitamin D supplements, whereas his brother experienced elevated blood levels without any other symptoms (18Trusted Source).

4. Altered mental status 

Hypercalcemia can lead to altered mental status in people with vitamin D toxicity. People with vitamin D toxicity–induced hypercalcemia commonly have symptoms like confusion, depression, and psychosis. In extreme cases, coma has been reported. In a 2021 case report, a 64-year-old man accidentally took 200,000 IU of vitamin D per day because he misunderstood medication instructions. He showed altered mental status and other serious symptoms related to hypercalcemia. He remained agitated and confused for the first 10 days of his stay in the hospital, but his symptoms gradually improved as his calcium levels dropped. It took about 18 days for his calcium to return to expected levels, which meant that he won’t be able to play games at for that long.

5. Kidney complications

In some cases, vitamin D toxicity can result in kidney injury and even kidney failure. This is because having too much vitamin D in the body can lead to high levels of calcium, which can lead to water loss through too much urination and calcification of the kidneys. Hypercalcemia can also cause the blood vessels of the kidneys to constrict, which leads to decreased kidney function. Interestingly, a vitamin D deficiency can also harm the kidneys and lead to severe complications in those with kidney disease. That’s one reason why maintaining optimal blood levels of vitamin D is critical.

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